The Effect of Khaya senegalensis on the Endometrial and Vaginal Epithelium: A Histological and Morphometrical Study

Introduction: Khaya senegalensis is a plant with many medicinal uses and application which could serve as an available alternative source of medication. It has been used traditionally abortifacient agent following folkloric information handed down by word mouth. The aim this study to validate claim investigating the effect extract on endometrial vaginal epithelium. Methodology: Four groups albino rats were administered different dosages orally after 28 days, sacrificed. micrographs uterus vagina studied for histologically observations. Morphometric analysis was also carried out determine thickness epithelial lining in all groups. Measurements analyzed one-way ANOVA followed Dunnett’s multiple comparisons test using GraphPad Prism. Results: Histological observations showed that at concentration 50mg/kg 200mg/kg disrupted concentrations increased, surface stromal glands became smaller sparse stroma less compact. revealed significant increase epithelium group least extract. Vaginal significantly reduced Conclusion: Results obtained suggests anti-fertility vagina. Further studies are recommended.